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KMID : 0379520020180030259
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한국독성학회지
2002 Volume.18 No. 3 p.259 ~ p.265
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Resveratrol Induces the Apoptosis of Osteosarcoma Saos-2 Cells
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Lee Hyun-Jang
Yang Jae-Hyun
Choi Ik-Jun
Choi Yee-Cheon
Kim Yong-Kweon
Lim Chang-In
Yun Jae-Do
Kim Ho-Chan
Won Jean-Sook
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Abstract
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Resveratrol, a phytoalexin found in grapes, berries, and peanuts, is one of the most promising agents for cancer prevention. Recent studies show that the antitumor activity of resveratrol occurs through p53-mediated apoptosis. This study demonstrated the mechanism that resveratrol induced apoptosis in human osteosarcoma Saos-2 cells lacking p53. Treatment of osteosarcoma Saos-2 cells with resveratrol resulted in decrease of cell viability, which was revealed as apoptosis characterized by activation of caspase-3 protease as well as cleavage of poly(ADP-ribose) polymerase (PARP) with change of mitochondrial membrane potential transition. These results suggest that resveratrol may be potentially useful to treat osteosarcoma via activation of caspase protease and mitochondrial dysfunction.
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KEYWORD
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Resveratrol, Osteosarcoma, p53, Apoptosis
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